Thermo Fisher Scientific ZAK Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

ZAK is a leucine zipper-containing mitogen-activated protein related to the MLKs in both sequence and function. Like the MLKs and other MAP3Ks, ZAK activates MAP2Ks. ZAK is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif.
This magnesium-binding protein forms homodimers and is located in the cytoplasm. It mediates gamma radiation signaling leading to cell cycle arrest and plays a role in cell cycle checkpoint regulation. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants encoding different isoforms have been characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.