Thermo Fisher Scientific Itch Polyclonal Antibody
Rabbit polyclonal antibody against Itch protein for Western blot applications. Unconjugated liquid form with 0.20 mg/mL concentration. Predicted cross-reactivity with mouse. Suitable for research use only, not for diagnostic or resale purposes.
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:2,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Between amino acids 650–700 of human ITCH (UniProt ID: Q96J02-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse
Target Information
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1 and belongs to the NEDD4-like protein family, which includes E3 ubiquitin-ligase molecules regulating key trafficking decisions such as targeting proteins to proteasomes or lysosomes.
This encoded protein contains four tandem WW domains and a HECT domain, can act as a transcriptional corepressor of p45/NFE2, and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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