Thermo Fisher Scientific Itch Polyclonal Antibody

Applications

• Western Blot (WB): 1:2,000–1:10,000

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse

Target Information

Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1 and belongs to the NEDD4-like protein family, which includes E3 ubiquitin-ligase molecules regulating key trafficking decisions such as targeting proteins to proteasomes or lysosomes.
This encoded protein contains four tandem WW domains and a HECT domain, can act as a transcriptional corepressor of p45/NFE2, and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.