Thermo Fisher Scientific Connexin 26 Polyclonal Antibody
Connexin 26 단백질을 인식하는 Goat Polyclonal Antibody로, WB, IHC, Flow Cytometry에 적합합니다. 인간, 생쥐, 랫트 반응성을 보이며, 0.5 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.01–1 µg/mL | - |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Flow Cytometry (Flow) | 10 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (YLLIRYCSGKSKKP) corresponding to the C-terminus amino acids of GJB2 (aa 212–225) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10982506 |
Product Specific Information
- Predicted to react with human and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Gap junctions are conduits that allow direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, mediating intercellular metabolic and electrical communication.
Gap junction channels consist of connexin protein subunits encoded by a multigene family.
GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels.
Defects in GJB3 have been linked to erythrokeratodermia variabilis (EKV), an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis.
Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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