Thermo Fisher Scientific GFAP (Astrocyte and Neural Stem Cell Marker) Monoclonal Antibody (SPM507)
GFAP 단백질을 표적으로 하는 SPM507 단클론 항체로, 신경교세포 및 신경줄기세포 마커로 사용됩니다. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합하며, 여러 종에 반응합니다. 연구용으로 고순도 Protein A/G 정제된 액상 형태 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Chicken, Human, Mouse, Pig, Rabbit, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM507 |
| Immunogen | GFAP isolated from pig spinal cord |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
GFAP (Glial fibrillary acidic protein) belongs to the class III intermediate filament family. It is specifically expressed in astrocytes and certain astroglia of the central nervous system, satellite cells of peripheral ganglia, and non-myelinating Schwann cells of peripheral nerves. Neural stem cells also strongly express GFAP.
Antibodies against GFAP are useful markers for identifying astrocytic cells. GFAP expression is observed in various brain tumors derived from astrocytic cells, as well as in lens epithelium, Kupffer cells of the liver, some salivary tumor cells, and occasionally in erythrocytes. It serves as a marker to distinguish astrocytes from other glial cells during development.
Mutations in the GFAP gene cause Alexander disease, a rare astrocyte-related disorder of the central nervous system. Alternative splicing of the GFAP gene produces multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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