Thermo Fisher Scientific HLA-DR/DP Monoclonal Antibody (MEM-136)
인간 HLA-DR/DP 항원을 인식하는 Mouse IgG1 단클론 항체로, WB, IHC, Flow Cytometry, IP에 적합합니다. Protein A로 정제된 액상 형태이며, PBS buffer와 sodium azide를 포함합니다. 항원제시세포 연구용으로 사용됩니다.
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Thermo Fisher Scientific HLA-DR/DP Monoclonal Antibody (MEM-136)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Flow Cytometry (Flow) | 1–4 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-136 |
| Immunogen | PHA-activated peripheral blood lymphocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1076780 |
Available Conjugated Formats
Product Specific Information
This antibody reacts with alpha/beta dimer as well as with dissociated beta-subunit.
DR and DP are the isotypes of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages).
Target Information
HLA-DRA is one of the HLA class II alpha chain paralogues. This molecule is a heterodimer consisting of alpha and beta chains anchored in the membrane, playing a central role in antigen presentation.
Class II molecules are expressed on APCs (B lymphocytes, dendritic cells, macrophages). The alpha chain (~33–35 kDa) gene contains 5 exons:
- Exon 1: leader peptide
- Exons 2–3: extracellular domains
- Exon 4: transmembrane domain and cytoplasmic tail
DRA has no polymorphisms in the peptide binding region and acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5.
HLA and MHC antibodies are crucial in Immunopeptidomics for identifying and characterizing neoantigens via LC-MS/MS analysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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