Thermo Fisher Scientific CD21 Monoclonal Antibody (LT21)

Applications

Immunohistochemistry (Frozen) (IHC (F))

• Assay-dependent

Flow Cytometry (Flow)

• 2 µg/mL

Product Specifications

Additional Formats

• Alexa Fluor 647
• FITC
• PE
• Request custom conjugation

Product Specific Information

This antibody reacts with an extracellular epitope of CD21 (CR2), a 145 kDa transmembrane glycoprotein (complement C3d receptor - C3dR) expressed on B lymphocytes, follicular dendritic cells, some epithelial cells and a subset of T lymphocytes. It is not expressed on immature B cells.

Target Information

CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen.
CD21 has important roles in:

• Uptake and retention of immunocomplexes
• Survival of memory B cells
• Development and maintenance of humoral response to T-dependent antigens

CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to follicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions.
A soluble form of CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.
CD21 functions as receptor for C3d, C3dg and iC3b complement components, for EBV and for IFNα.
It binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.
Genetic variations in the CD21 gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9).
Alternatively spliced transcript variants encoding different isoforms of CD21 have been found.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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