Thermo Fisher Scientific DKK3 Monoclonal Antibody (8A5C6)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-17067 targets DKK3 in FACS, IHC, indirect ELISA, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human DKK3 (amino acids 91–350) expressed in E. coli.
MA5-17067 detects DKK3, which has a predicted molecular weight of approximately 38.3 kDa.

Target Information

DKK3, like DKK1, DKK2, and DKK4, possesses an N-terminal signal peptide and two conserved cysteine-rich domains separated by a linker region, each containing 10 cysteine residues.
The second cysteine region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane.
The linker region contains 50–55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids.
All DKKs have potential sites for cleavage by furin-type proteases.
Northern blot analysis shows wide expression of DKK3 transcript, with highest levels in heart, brain, and spinal cord. In situ hybridization reveals highest expression in mouse brain, eye, and heart.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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