Thermo Fisher Scientific Phospho-CD247 (CD3 zeta) (Lys72) Monoclonal Antibody (EM-26), Alexa Fluor 647

Applications

Immunocytochemistry (ICC/IF)

• Assay-dependent

Flow Cytometry (Flow)

• 2–6 µg/mL

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 488
• Request custom conjugation

Product Specific Information

This antibody recognizes phosphorylated intracellular tyrosine 72 of CD3 zeta chain (CD247), which is a component of the TCR/CD3 complex expressed on T cells.

Target Information

The CD3z complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and regulating the surface expression of the TCR complex.
T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits (γ, δ, ε, ζ), which are structurally related members of the immunoglobulin superfamily encoded on human chromosome 11.
These subunits contain double tyrosine-based motifs that mediate association with cytoplasmic signal transduction molecules.
CD3 antigens are present on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum, but not on B or NK cells.
Decreased T lymphocyte percentages may occur in certain autoimmune diseases.
Diseases associated with CD3z include Immunodeficiency 25 and T-B+ Severe Combined Immunodeficiency due to CD3δ/ε/ζ defects.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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