Thermo Fisher Scientific Phospho-CD247 (CD3 zeta) (Lys111) Monoclonal Antibody (EM-55), Alexa Fluor 488

Applications

• Flow Cytometry (Flow)

Tested Dilution: 1–12 µg/mL
Publications: –

Product Specifications

Additional Formats

• Unconjugated: MA5-28539
• Alexa Fluor 647: MA5-38689
• Custom conjugation available upon request

Product Specific Information

This antibody recognizes phosphorylated intracellular tyrosine 111 of CD3 zeta chain (CD247), which is a component of the TCR/CD3 complex expressed on T cells.

Target Information

The CD3z complex is crucial for transducing antigen-recognition signals into the cytoplasm of T cells and regulating TCR complex surface expression.
T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of CD3 subunits (γ, δ, ε, ζ), which contain tyrosine-based motifs mediating signal transduction.
CD3 is expressed on most normal peripheral blood lymphocytes and thymocytes but not on B or NK cells.
Abnormal CD3 expression is associated with Immunodeficiency 25 and T-B+ Severe Combined Immunodeficiency due to CD3δ/CD3ε/CD3ζ defects.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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