Thermo Fisher Scientific Phospho-CD247 (CD3 zeta) (Lys153) Monoclonal Antibody (EM-17), Alexa Fluor 647

Applications

• Flow Cytometry (Flow): 2–6 µg/mL

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 488
• Request custom conjugation

Product Specific Information

This antibody recognizes phosphorylated intracellular tyrosine 153 of CD3 zeta chain (CD247), which is a component of the TCR/CD3 complex expressed on T cells.

Target Information

The CD3z complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex.
T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits (CD3 gamma, CD3 delta, CD3 epsilon, and CD3 zeta). These subunits are structurally related members of the immunoglobulin superfamily encoded by closely linked genes on human chromosome 11.

CD3 subunits have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules, mediated in part by a double tyrosine-based motif.
CD3 is present on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum. It is not expressed on B or NK cells.
Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.

Diseases associated with CD3z include:

• Immunodeficiency 25
• T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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