Thermo Fisher Scientific HLA-G Monoclonal Antibody (MEM-G/11)
인간 HLA-G 항원을 인식하는 Mouse IgG1 단일클론 항체로, IHC, Flow Cytometry, ELISA, IP에 사용 가능. 비결합형 액상 포맷이며 Protein A로 정제됨. 4°C 보관, 동결 금지. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | — |
| Flow Cytometry (Flow) | 2 µg/mL | — |
| ELISA | Assay-dependent | — |
| Immunoprecipitation (IP) | Assay-dependent | — |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-G/11 |
| Immunogen | Recombinant human HLA-G refolded with beta-2 Microglobulin and peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1076739 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope of HLA-G1 antigen.
HLA-G belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and is expressed on the surface of trophoblast cells.
Target Information
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal-derived placental cells.
The heavy chain (~45 kDa) gene contains 8 exons:
- Exon 1: leader peptide
- Exons 2–3: α1 and α2 domains (peptide-binding)
- Exon 4: α3 domain
- Exon 5: transmembrane region
- Exon 6: cytoplasmic tail
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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