Thermo Fisher Scientific Blood Group Lewis A Monoclonal Antibody (7LE)

Applications

Product Specifications

Product Specific Information

This antibody recognizes Lewis A blood group antigen, a carbohydrate determinant carried on both glycolipids and glycoproteins, expressed on colonic epithelial cells.
Lewis A may be useful for detection of gastrointestinal, pancreatic, and colorectal tumors.

For IHC (P), heat-mediated antigen retrieval in sodium citrate is recommended.

Target Information

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids synthesized by exocrine epithelial cells and circulating in body fluids.
These glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion.
They are secondarily absorbed to red blood cells, giving rise to their Lewis phenotype.

The gene encoding this antigen is part of the fucosyltransferase family, catalyzing the addition of fucose to precursor polysaccharides in the final step of Lewis antigen biosynthesis.
It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities.
Mutations in this gene cause Lewis antigen-negative phenotypes.
Multiple alternatively spliced variants encoding the same protein have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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