Thermo Fisher Scientific CD21/CD35 Recombinant Rat Monoclonal Antibody (7G6)
Thermo Fisher의 CD21/CD35 Recombinant Rat Monoclonal Antibody (7G6)은 마우스 CD21 및 CD35를 인식하는 재조합 단클론 항체로, 다양한 면역분석(WB, IHC, Flow 등)에 사용됩니다. 높은 특이성과 재현성을 제공하며, Protein A로 정제된 액상 형태로 공급됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
| T-Cell Activation (TCA) | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2b, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7G6 |
| Immunogen | Purified Mouse CR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
Recognises an epitope shared by 145–150 kDa and 190 kDa complement receptor proteins, originally designated CR2 (CD21) and CR1 (CD35).
Target Information
CD21 (complement receptor 2, CR2) binds C3 complement fragments, particularly breakdown fragments covalently attached to complement-activating surfaces or antigens. It plays key roles in immunocomplex uptake, memory B-cell survival, and humoral response maintenance. CD21 also serves as a receptor for Epstein-Barr virus and is involved in prion targeting to follicular dendritic cells.
CD35 encodes a membrane glycoprotein expressed on peripheral blood cells, glomerular podocytes, and follicular dendritic cells. It functions as a receptor for complement components C3b and C4b, regulating complement cascade activity. Variations in CD35 form the basis of the Knops blood group system. A secreted plasma form has been described, though its full-length structure is undetermined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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