Thermo Fisher Scientific CD4 Monoclonal Antibody (44.38), FITC

Applications

• Flow Cytometry (Flow): Tested neat at 1:10 dilution

Product Specifications

Additional Formats

• Unconjugated (MA5-28358)
• PE conjugate (MA1-81450)
• Custom conjugation available upon request

Product Specific Information

For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
Mouse anti-Sheep CD4 antibody, clone 44.38, recognizes the ovine CD4 cell surface glycoprotein expressed by a subset of mature T lymphocytes.

Target Information

The CD4 antigen is involved in the recognition of MHC class II molecules and serves as a co-receptor for HIV.
CD4 is primarily expressed in T helper cells but may also be found in monocytes, macrophages, and dendritic cells.
At the tissue level, CD4 expression can be detected in thymus, lymph nodes, tonsils, spleen, and specific regions of brain and gut.
CD4 functions to initiate or enhance T-cell activation through association with the T-cell receptor complex and protein tyrosine kinase Lck.
It may also play a role in neuronal damage in infectious and immune-mediated CNS diseases.
Multiple alternatively spliced transcripts have been identified (RefSeq, July 2017).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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