Thermo Fisher Scientific Phospho-E-cadherin (Ser844) Polyclonal Antibody
E-cadherin의 Ser844 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 적합. 인간, 마우스, 랫드, 영장류 반응성. 1 mg/mL 농도의 액상 제품으로 -20°C 보관.
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- PA5118736
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CDH1 (Accession P12830), corresponding to amino acid residues around phosphorylated Ser844. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2903236 |
Product Specific Information
This antibody detects endogenous levels of E-cadherin only when phosphorylated at Ser844.
Target Information
E-Cadherin (epithelial cadherin) is a classical cadherin belonging to the calcium-dependent adhesion protein superfamily. It is a glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail. Mutations in the CDH1 gene encoding E-cadherin are associated with various cancers, including gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of E-cadherin function contributes to tumor progression by promoting proliferation, invasion, and metastasis. The ectodomain mediates bacterial adhesion to mammalian cells, while the cytoplasmic domain is required for internalization. Reduction or loss of E-cadherin expression correlates with increased tumor invasiveness and metastatic potential. In humans, E-cadherin is encoded by the CDH1 gene located on chromosome 16.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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