Thermo Fisher Scientific Phospho-ASAP2 (Ser701) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

This antibody detects endogenous levels of ASAP2 only when phosphorylated at Ser701.

Target Information

ASAP2 is a multidomain protein belonging to the beta family with two ANK repeats, an Arf-GAP domain, a PH domain, and a SH3 domain.
It localizes in the Golgi apparatus and plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2) and forms a stable complex in vivo.
ASAP2 is tyrosine phosphorylated by activated PYK2 and functions as a substrate and downstream target for PYK2 and SRC, which may regulate vesicular transport.
It activates small GTPases ARF1, ARF5, and ARF6, regulating post-Golgi vesicle formation and constitutive secretion.
ASAP2 also modulates Fc gamma receptor-mediated phagocytosis and ARF6 activity.
Detected in heart, brain, placenta, kidney, monocytes, and pancreas, ASAP2 expression increases during monocyte maturation.
Multiple transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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