Thermo Fisher Scientific Human RIM2 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 16 amino acids near the carboxy terminus of human RIM2.
PEP-1600 can be used as a blocking peptide with polyclonal antibody PA5-34557.
For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37ºC.

Target Information

Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain.
While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality due to defects in neurotransmitter release.
Synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca²⁺ triggers.
Like Rim1, Rim2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.