Thermo Fisher Scientific Human SCUBE3 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the center of human SCUBE3.
PEP-1601 can be used as a blocking peptide with polyclonal antibody PA5-34558.
For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37ºC.

Target Information

SCUBE3 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain. It is highly expressed in primary osteoblasts and bones, and to a lesser extent in heart.
Overexpression of SCUBE3 in mice induced cardiac hypertrophy, suggesting a role in cardiac growth regulation.
SCUBE3 has been shown to be an endogenous TGF-Beta receptor ligand and may promote lung cancer cell mobility and invasiveness. In lung cancer cells, SCUBE3 is cleaved by MMP2 and MMP9, activating the TGF-Beta receptor and increasing Smad2/3 transcriptional activity and expression of proteins such as TGF-Beta1, VEGF, Snail, and Slug.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.