Thermo Fisher Scientific Human SCUBE3 Synthetic Peptide
Human SCUBE3 단백질의 중심부 15개 아미노산에 해당하는 합성 펩타이드로, PA5-34558 항체의 블로킹 용도로 사용 가능. 인간 특이적 반응성을 가지며 액상 형태로 제공. 연구용으로만 사용 가능하며 -20°C에서 보관.
- 카탈로그번호
- PEP1601
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the center of human SCUBE3.
PEP-1601 can be used as a blocking peptide with polyclonal antibody PA5-34558.
For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37ºC.
Target Information
SCUBE3 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain. It is highly expressed in primary osteoblasts and bones, and to a lesser extent in heart.
Overexpression of SCUBE3 in mice induced cardiac hypertrophy, suggesting a role in cardiac growth regulation.
SCUBE3 has been shown to be an endogenous TGF-Beta receptor ligand and may promote lung cancer cell mobility and invasiveness. In lung cancer cells, SCUBE3 is cleaved by MMP2 and MMP9, activating the TGF-Beta receptor and increasing Smad2/3 transcriptional activity and expression of proteins such as TGF-Beta1, VEGF, Snail, and Slug.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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