Thermo Fisher Scientific SCN10A Monoclonal Antibody (S134), FITC
SCN10A 단백질을 인식하는 FITC 결합 단클론 항체. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 인간, 마우스, 랫드 등 반응. 단백질 G 정제, 4°C 암소 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host/Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S134 |
| Immunogen | Fusion protein amino acids 1724–1956 of rat Nav1.8 |
| Conjugate | FITC |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 9.1 mM sodium bicarbonate/PBS, pH 7.4, with 640.91 mM DMSO, 136.36 mM ethanolamine |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931924 |
Additional Formats Available
- Unconjugated (MA5-27663)
- APC (MA5-45469)
- PE (MA5-45472)
- PerCP (MA5-45471)
- Custom conjugation available upon request
Product Specific Information
1 µg/mL of MA5-45470 was sufficient for detection of Nav1.8 in 10 µg of COS cell lysate transiently expressing Nav1.8 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 220 kDa. No cross-reactivity against other Nav channels observed.
Target Information
Scn10a is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. It mediates voltage-dependent sodium ion permeability of excitable membranes, forming sodium-selective channels that respond to voltage differences across membranes. Scn10a plays a role in neuropathic pain mechanisms.
Members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily share structural similarity, with two short intracellular termini, two membrane-spanning segments, and a large extracellular loop containing conserved cysteine-rich regions. ENaC isoforms (α, β, γ) are involved in sodium and fluid balance in kidney, lung, and colon, and regulate blood pressure via aldosterone-dependent sodium reabsorption. Mutations in ENaC subunits are associated with disorders such as Liddle’s syndrome and pseudohypoaldosteronism (PHA-1). Diseases associated with SCN10A include Episodic Pain Syndrome, Familial type 2, and Sodium Channelopathy-Related Small Fiber Neuropathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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