Thermo Fisher Scientific SCN10A Monoclonal Antibody (S134), FITC

Applications and Tested Dilution

Product Specifications

Additional Formats Available

• Unconjugated (MA5-27663)
• APC (MA5-45469)
• PE (MA5-45472)
• PerCP (MA5-45471)
• Custom conjugation available upon request

Product Specific Information

1 µg/mL of MA5-45470 was sufficient for detection of Nav1.8 in 10 µg of COS cell lysate transiently expressing Nav1.8 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 220 kDa. No cross-reactivity against other Nav channels observed.

Target Information

Scn10a is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. It mediates voltage-dependent sodium ion permeability of excitable membranes, forming sodium-selective channels that respond to voltage differences across membranes. Scn10a plays a role in neuropathic pain mechanisms.

Members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily share structural similarity, with two short intracellular termini, two membrane-spanning segments, and a large extracellular loop containing conserved cysteine-rich regions. ENaC isoforms (α, β, γ) are involved in sodium and fluid balance in kidney, lung, and colon, and regulate blood pressure via aldosterone-dependent sodium reabsorption. Mutations in ENaC subunits are associated with disorders such as Liddle’s syndrome and pseudohypoaldosteronism (PHA-1). Diseases associated with SCN10A include Episodic Pain Syndrome, Familial type 2, and Sodium Channelopathy-Related Small Fiber Neuropathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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