Thermo Fisher Scientific SCN10A Monoclonal Antibody (S134), PerCP
SCN10A 단백질을 인식하는 S134 클론의 PerCP 결합 단일클론 항체입니다. 사람, 생쥐, 설치류 등 다양한 종에서 반응하며 WB, IHC, ICC 등 여러 응용에 사용 가능합니다. 482/675 nm 형광 특성을 가지며 단백질 G로 정제된 액상 형태입니다.
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Thermo Fisher Scientific SCN10A Monoclonal Antibody (S134), PerCP
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S134 |
| Immunogen | Fusion protein amino acids 1724–1956 of rat Nav1.8 |
| Conjugate | PerCP |
| Excitation / Emission Max | 482 / 675 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931925 |
Additional Formats
Product Specific Information
1 µg/mL of MA5-45471 was sufficient for detection of Nav1.8 in 10 µg of COS cell lysate transiently expressing Nav1.8 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 220 kDa. No cross reactivity against other Nav channels.
Target Information
Scn10a is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. It mediates voltage-dependent sodium ion permeability of excitable membranes and plays a role in neuropathic pain mechanisms. Structurally, members of the Deg/ENaC superfamily share similarity with two short intracellular termini, two membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.
ENaC in kidney, lung, and colon regulates sodium and fluid balance, and aldosterone-dependent sodium reabsorption in the distal nephron, thus influencing blood pressure. Mutations in ENaC subunits can lead to conditions such as Liddels syndrome or pseudohypoaldosteronism (PHA-1). Diseases associated with SCN10A include Episodic Pain Syndrome, Familial, 2 and Sodium Channelopathy-Related Small Fiber Neuropathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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