Thermo Fisher Scientific SCN10A Monoclonal Antibody (S134), APC
SCN10A 단백질을 인식하는 단일클론 항체로, APC 형광 표지된 제품입니다. Western blot, IHC, ICC/IF 등 다양한 응용에 사용 가능하며, 인간, 마우스, 설치류 등에서 반응합니다. 단백질 G 정제, 보존제 무첨가, 4°C 보관 조건입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S134 |
| Immunogen | Fusion protein amino acids 1724–1956 of rat Nav1.8 |
| Conjugate | APC |
| Excitation/Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931923 |
Additional Formats
- Unconjugated (MA5-27663)
- FITC (MA5-45470)
- PE (MA5-45472)
- PerCP (MA5-45471)
- Custom conjugation available upon request
Product Specific Information
1 µg/mL of MA5-45469 was sufficient for detection of Nav1.8 in 10 µg of COS cell lysate transiently expressing Nav1.8 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 220 kDa. No cross-reactivity against other Nav channels.
Target Information
Scn10a is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. It mediates voltage-dependent sodium ion permeability in excitable membranes and plays a role in neuropathic pain mechanisms. Members of the Deg/ENaC superfamily share structural similarity with two short intracellular termini, two membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.
ENaC proteins (alpha, beta, gamma) are essential for sodium and fluid balance in kidney, lung, and colon, and are regulated partly through association with CFTR chloride channels. Mutations in ENaC subunits are associated with conditions such as Liddle’s syndrome and pseudohypoaldosteronism (PHA-1). Diseases linked to SCN10A include Episodic Pain Syndrome, Familial 2, and Sodium Channelopathy-Related Small Fiber Neuropathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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