Thermo Fisher Scientific Tyrosine Hydroxylase Polyclonal Antibody
Zebrafish Tyrosine Hydroxylase를 인식하는 Rabbit Polyclonal Antibody로, Western Blot에 최적화됨. Recombinant 단백질(1-110aa)을 면역원으로 사용. 고순도 Protein G 정제 및 PBS/glycerol buffer 저장. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Tyrosine Hydroxylase Polyclonal Antibody
Applications
- Western Blot (WB): Tested dilution 1:500–1:5,000
- Direct-ELISA: Tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Zebrafish Tyrosine hydroxylase protein (1–110aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.886 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2902160 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters — dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with the cofactor tetrahydrobiopterin (BH4), which binds to the TH catalytic domain to activate enzymatic function.
In humans, four TH mRNA splice variants (hTH1–hTH4) have been identified, differing in the N-terminal regulatory domains but sharing identical catalytic domains. TH catalyzes the conversion of L-tyrosine to L-dopa and plays a crucial role in adrenergic neuron physiology.
Alterations in TH activity are associated with neuropathogenic diseases such as Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and various cardiovascular disorders.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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