Thermo Fisher Scientific EGF Polyclonal Antibody
Zebrafish EGF 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot에 최적화됨. Protein G로 정제된 액상 항체이며 PBS와 glycerol buffer로 안정화. 세포 신호전달 연구 및 EGF 관련 단백질 분석에 적합.
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:500–1:5,000
- Tested in direct-ELISA
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Zebrafish Pro-epidermal growth factor protein (1063–1176aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 4.014 mg/mL |
| Purification | Protein G |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% ProClin 300 |
| Storage conditions | -20°C or -80°C if preferred |
| Shipping conditions | Wet ice |
| RRID | AB_2902161 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
Epidermal growth factor (EGF) binds to the EGF receptor (EGFR), a 170 kDa protein kinase, initiating multiple signaling pathways in response to environmental stimuli. Upon EGF binding, EGFR forms homo- or heterodimers with other family members, triggering distinct downstream cascades through recruitment of SH2-containing effector proteins.
EGF is widely expressed in kidney, cerebrum, prostate, and salivary glands, acting as a potent mitogenic factor. The phosphorylated receptor recruits adapter proteins such as GRB2, activating RAS-RAF-MEK-ERK, PI3K-AKT, PLCγ-PKC, and STAT signaling modules. Studies also suggest involvement in NF-κB activation.
Mutations in the EGF gene are linked to hypomagnesemia type 4, and dysregulation is associated with cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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