Thermo Fisher Scientific CD19 Monoclonal Antibody (HIB19), APC, eBioscience
인간 CD19를 표적으로 하는 HIB19 단클론 항체로, APC로 결합되어 유세포분석(Flow Cytometry)에 최적화됨. B세포 발현 분석에 활용 가능하며, 633–647 nm 레이저에 적합. 액상 형태로 4°C에서 보관, 동결 금지.
- 카탈로그번호
- 17-0199-4x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD19 Monoclonal Antibody (HIB19), APC, eBioscience
Applications
- Flow Cytometry (Flow): 5 µL (0.125 µg)/test
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HIB19 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10804641 |
Available Formats
- Unconjugated
- Alexa Fluor 488, 532, 561, 660, 700
- APC-eFluor 780
- Biotin
- Brilliant UV, Violet, and Yellow series
- eFluor 450, 506
- FITC
- Functional Grade
- NovaFluor Blue, Red, Violet, Yellow series
- PE, PE-Cyanine5, PE-Cyanine7, PE-eFluor 610
- PerCP-Cyanine5.5, PerCP-eFluor 710
- Super Bright 436, 600, 645, 702, 780
- Request custom conjugation
Product Specific Information
Description:
The HIB19 monoclonal antibody reacts with human CD19, a 95 kDa transmembrane glycoprotein expressed on B cells throughout development, excluding terminally differentiated plasma cells. Follicular dendritic cells also express CD19. CD19 forms a multimolecular complex with CD21, CD81, Leu13, and MHC class II, associated with the B cell receptor (BCR). Signaling through CD19 induces tyrosine phosphorylation, calcium flux, and proliferation of B cells. The SJ25C1 and HIB19 antibodies recognize overlapping epitopes.
Applications Reported:
Reported for use in flow cytometric analysis.
Applications Tested:
Pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. Recommended usage: 5 µL (0.125 µg) per test in a final volume of 100 µL. Cell number can range from 10⁵ to 10⁸ cells/test.
Excitation / Emission:
633–647 nm / 660 nm (Red Laser)
Filtration:
0.2 µm post-manufacturing filtered.
Target Information
CD19 is a member of the immunoglobulin superfamily with two Ig-like domains. It is expressed on 100% of peripheral B cells and may be found on some myeloid leukemia cells. CD19 serves as a critical regulator of normal and malignant B cell proliferation and is expressed in all B cell precursor leukemias. It functions as a signal-amplifying co-receptor for the B cell receptor (BCR) and can signal independently. Mutations in CD19 can lead to hypogammaglobulinemia, while overexpression may cause B cell hyperactivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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