Thermo Fisher Scientific CD21 Monoclonal Antibody (HB5), APC, eBioscience

Thermo Fisher Scientific CD21 Monoclonal Antibody (HB5), APC, eBioscience

Applications

• Flow Cytometry (Flow)

Tested Dilution: 5 µL (0.03 µg)/test
Publications: View 6 publications

Product Specifications

Additional Formats Available

• FITC
• NovaFluor Blue 610-70S
• NovaFluor Blue 660-120S
• NovaFluor Red 710
• NovaFluor Red 725
• NovaFluor Red 755
• NovaFluor Yellow 610
• NovaFluor Yellow 660
• PE
• PE-Cyanine7
• PerCP-eFluor 710
• Super Bright 436
• Super Bright 600
• Request custom conjugation

Product Specific Information

The HB5 monoclonal antibody reacts with human CD21, an approximately 145 kDa type I transmembrane protein. CD21 is expressed by mature B cells, follicular dendritic cells, and a subset of epithelial cells, functioning as a receptor for complement component C3d and Epstein-Barr virus (EBV).
CD21, in association with CD19 and CD81, participates in the multimolecular complex with BCR and is involved in B cell activation.

Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. Recommended use at 5 µL (0.03 µg) per test (100 µL final volume).
Excitation: 633–647 nm; Emission: 660 nm; Laser: Red Laser.
Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments and plays roles in uptake and retention of immune complexes, survival of memory B cells, and maintenance of humoral responses.
It serves as a receptor for Epstein-Barr virus and participates in prion targeting to follicular dendritic cells. Soluble CD21 (sCD21) retains ligand-binding ability.
CD21 interacts with CD23 and associates with CD19, CD81, and Leu13 to form a signal-transduction complex involved in B cell activation.
Genetic variations in CD21 are linked to susceptibility to systemic lupus erythematosus type 9 (SLEB9).
Alternative splicing results in different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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