Thermo Fisher Scientific INPP5E Polyclonal Antibody
INPP5E 단백질을 검출하는 Thermo Fisher Scientific의 폴리클로날 항체입니다. Western blot에 최적화되어 있으며, 인간·마우스·랫트 반응성. 고순도(>95%) 항원 친화 크로마토그래피 정제. 장기 보관 시 -20°C에서 안정적 유지.
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Thermo Fisher Scientific INPP5E Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Publications: - [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in human INPP5E |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553915 |
Product Specific Information
- Detects endogenous INPP5E protein at a molecular weight of 72 kDa.
- Purity >95% by SDS-PAGE.
Target Information
INPP5E (inositol polyphosphate 5-phosphatase), also known as phosphatidylinositol polyphosphate 5-phosphatase type IV, is a 644 amino acid peripheral membrane protein associated with Golgi stacks.
It belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type IV family and converts phosphatidylinositol-3,4,5-triphosphate (PtdIns 3,4,5-P3) to PtdIns-P2.
INPP5E is inactive towards water-soluble inositol phosphates and specifically acts on lipid substrates.
It becomes phosphorylated upon DNA damage and is expressed in brain, heart, pancreas, testis, and spleen.
Defects in INPP5E cause Joubert syndrome type 1 (JBTS1) and may also lead to MORMS (mental retardation-truncal obesity-retinal dystrophy-micropenis syndrome).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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