Thermo Fisher Scientific CNTF Monoclonal Antibody (34738)
Rat CNTF 단백질을 표적으로 하는 Mouse IgG2b 단클론 항체. IHC, ELISA, Neutralization 실험에 적합. 재조합 rat CNTF 항원을 면역원으로 사용하며, 단백질 A/G로 정제된 동결건조 형태. 인간 CNTF와의 교차 반응은 3% 이하.
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Thermo Fisher Scientific CNTF Monoclonal Antibody (Clone 34738)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| ELISA | 0.1–0.4 µg/mL (Detection), 2–8 µg/mL (Capture) | View publication |
| Neutralization | 1–3 µg/mL | View publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Rat |
| Published Species | Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 34738 |
| Immunogen | E. coli-derived recombinant rat CNTF (Ala2–Met200) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609246 |
Product Specific Information
- In sandwich ELISAs, less than 3% cross-reactivity with recombinant human CNTF is observed.
- Reconstitute at 0.5 mg/mL in sterile PBS.
- Endotoxin level is <1.0 EU per 1 µg of antibody (LAL method).
Target Information
The CNTF protein is a polypeptide hormone primarily active in the nervous system, promoting neurotransmitter synthesis and neurite outgrowth in specific neuronal populations. It acts as a potent survival factor for neurons and oligodendrocytes, potentially reducing tissue destruction during inflammatory events.
Mutations causing aberrant splicing lead to CNTF deficiency but are not directly linked to neurologic disease. A read-through transcript variant combining ZFP91 and CNTF sequences has been observed but is considered non-coding.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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