Thermo Fisher Scientific IL-13 Monoclonal Antibody (38213)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In ELISAs, this antibody shows less than 0.1% cross-reactivity with recombinant human IL-13.
• Reconstitute at 0.5 mg/mL in sterile PBS.
• Endotoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Target Information

IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells and is involved in regulating inflammatory and immune responses.
It down-regulates macrophage activity, inhibiting the production of pro-inflammatory cytokines and chemokines, and plays a role in allergen-induced asthma through mechanisms independent of IgE and eosinophils.
IL-13 regulates several stages of B cell maturation and differentiation, up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells.
Structurally, IL-13 closely resembles IL-3, IL-4, IL-5, and GM-CSF.
The gene encoding IL-13, together with IL3, IL5, IL4, and CSF2, forms a cytokine gene cluster on chromosome 5q, with the IL-13 gene located particularly close to IL4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.