Thermo Fisher Scientific IL-13 Monoclonal Antibody (38213)
Mouse IL-13 단백질을 인식하는 Rat IgG2a 단클론 항체로, WB, ELISA, Neutralization에 사용 가능. 낮은 교차반응(<0.1%)과 높은 특이성 제공. 동결건조 형태로 제공되며, 재구성 후 PBS 내 0.5 mg/mL 농도 유지.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| ELISA (Detection) | 0.1–0.4 µg/mL |
| ELISA (Capture) | 2–8 µg/mL |
| Neutralization (Neu) | 0.3–0.8 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 38213 |
| Immunogen | E. coli-derived recombinant mouse IL-13 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609256 |
Product Specific Information
- In ELISAs, this antibody shows less than 0.1% cross-reactivity with recombinant human IL-13.
- Reconstitute at 0.5 mg/mL in sterile PBS.
- Endotoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells and is involved in regulating inflammatory and immune responses.
It down-regulates macrophage activity, inhibiting the production of pro-inflammatory cytokines and chemokines, and plays a role in allergen-induced asthma through mechanisms independent of IgE and eosinophils.
IL-13 regulates several stages of B cell maturation and differentiation, up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells.
Structurally, IL-13 closely resembles IL-3, IL-4, IL-5, and GM-CSF.
The gene encoding IL-13, together with IL3, IL5, IL4, and CSF2, forms a cytokine gene cluster on chromosome 5q, with the IL-13 gene located particularly close to IL4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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