Thermo Fisher Scientific ACVR2A Monoclonal Antibody (OTI8C7), TrueMAB
ACVR2A 단백질을 인식하는 Mouse IgG1 단클론 항체로 Western blot에 적합합니다. Human 시료 반응성이 있으며, 액상 형태로 1 mg/mL 농도입니다. Affinity chromatography로 정제되었으며, PBS/BSA/glycerol buffer에 보관됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8C7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 214–513 of human ACVR2A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor Serine/Threonine kinases.
ACVR2A is involved in the activin and myostatin signaling pathway.
Aliases: ACVR2, ACTRII
These receptors are transmembrane proteins composed of:
- Ligand-binding extracellular domain with cysteine-rich region
- Transmembrane domain
- Cytoplasmic domain with serine/threonine kinase specificity
Type I receptors are essential for signaling, while type II receptors bind ligands and facilitate type I receptor expression.
Upon ligand binding, Type I and II receptors form a stable complex, leading to phosphorylation of Type I receptors by Type II receptors.
Type II receptors are considered constitutively active kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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