Thermo Fisher Scientific HSF2 Monoclonal Antibody (OTI2E2), TrueMAB
Human HSF2 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot에 최적화됨. TrueMAB 형식으로 고순도 친화 크로마토그래피 정제. 액상 형태, PBS/BSA/glycerol buffer로 안정적 보관. 연구용으로 열충격 반응 관련 단백질 분석에 적합.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2E2 |
| Immunogen | Human recombinant protein fragment (aa 74–324 of human HSF2, produced in E. coli) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Prokaryotic and eukaryotic cells respond to thermal and chemical stress by inducing heat shock genes. In eukaryotes, transcriptional regulation involves heat shock transcription factors (HSF1 and HSF2).
HSF1 and HSF2 are upregulated by estrogen at both mRNA and protein levels. HSF1 typically exists as a monomer with repressed activity due to phosphorylation, but upon activation forms trimers with DNA binding activity and translocates to the nucleus.
HSF2 is associated with differentiation and development and also binds DNA as a trimer. Both factors are induced by proteasome inhibitors in the ubiquitin pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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