Thermo Fisher Scientific Cyclin T1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
• Based on 100% sequence identity, this antibody is predicted to react with Chimpanzee.

Target Information

This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9 (CDK9) and forms a major subunit of positive transcription elongation factor b (p-TEFb). In humans, multiple forms of p-TEFb exist, each potentially containing different cyclins and CDK9.

The Cyclin T1–CDK9 complex acts as a cofactor of the HIV-1 Tat protein and is essential for full activation of viral transcription. This complex also facilitates transcript elongation via phosphorylation of the carboxy-terminal domain of RNA polymerase II. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.