Thermo Fisher Scientific c-Myc Oncoprotein Monoclonal Antibody (SPM237)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Does not react with Mouse, Rat, or Chicken.

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene located on human chromosome 8q24. It is commonly activated in various tumor cells and plays a key role in cellular proliferation, differentiation, apoptosis, and cell cycle progression.

Phosphorylation of c-Myc, particularly at Thr58/Ser62 by kinases such as glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK, is associated with regulation of cell proliferation and cycle control. c-Myc is essential for vasculogenesis and angiogenesis during tumor development.

The c-myc oncogene (p62 c-myc) regulates normal cellular proliferation and differentiation, while deregulated expression can induce apoptosis. Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to either terminal of target proteins.

Amplification of the c-Myc gene has been observed in human tumors such as lung, breast, and colon carcinomas, whereas N-Myc amplification is found in neuroblastomas. Chromosomal translocations involving c-Myc (chromosome 8) and immunoglobulin loci (chromosomes 14, 2, or 22) are characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative disorders. Aberrant c-Myc expression is found in tumors of diverse origins including colorectal, gastric, hepatic, mammary, ovarian, pulmonary, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.