Thermo Fisher Scientific c-Myc Oncoprotein Monoclonal Antibody (MYC909)

Applications and Tested Dilution

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays key roles in cellular proliferation, differentiation, apoptosis, and cell cycle progression.

Phosphorylation of c-Myc at Thr58/Ser62 by kinases such as glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK is functionally associated with cell proliferation and cycle regulation. c-Myc is essential for vasculogenesis and angiogenesis in tumor development.

The c-myc oncogene (p62 c-myc) regulates normal cellular proliferation and differentiation, and its deregulated expression can induce apoptosis. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tags at either amino- or carboxy-termini.

c-Myc-, N-Myc-, and L-Myc-encoded proteins function in cell proliferation, differentiation, and neoplastic disease. Amplification of the c-Myc gene is observed in lung, breast, and colon carcinomas, while N-Myc amplification is found in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to immunoglobulin loci on chromosomes 14, 2, or 22 is characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative conditions. Aberrant expression of c-myc occurs in tumors of various origins, including colorectal, gastric, hepatic, mammary, ovarian, pulmonary, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.