Thermo Fisher Scientific Phospho-ASAP2 (Tyr724) Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:1,000

Product Specifications

Target Information

ASAP2 is a multidomain protein belonging to the beta family with two ANK repeats, an Arf-GAP domain, a PH domain, and a SH3 domain. It localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2) and forms a stable complex with PYK2 in vivo. ASAP2 is tyrosine phosphorylated by activated PYK2 and functions as a substrate and downstream target for PYK2 and SRC, possibly regulating vesicular transport. It activates small GTPases ARF1, ARF5, and ARF6, regulates post-Golgi vesicle formation, and modulates constitutive secretion. It also modulates Fc gamma receptor-mediated phagocytosis and ARF6 activity. ASAP2 is usually detected in heart, brain, placenta, kidney, monocytes, and pancreas, and is up-regulated during monocyte maturation. Multiple transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.