Thermo Fisher Scientific ALK Monoclonal Antibody (OTI13A1), TrueMAB
인간 ALK 단백질(aa 1060-1620)을 인식하는 Rat IgG2a 단클론 항체로, Western blot에 최적화되어 있습니다. 동결건조 형태로 제공되며, 1 mg/mL 농도, PBS(pH 7.3, 8% trehalose) 버퍼에 저장됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific ALK Monoclonal Antibody (OTI13A1), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI13A1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1060–1620 of human ALK produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a vital role in brain development.
Mutations, rearrangements, and amplifications of the ALK gene are associated with various tumors, including:
- Anaplastic large cell lymphoma
- Neuroblastoma
- Non-small cell lung cancer
Chromosomal rearrangements often lead to fusion genes such as NPM-ALK, which are oncogenic.
ALK encodes a receptor protein-tyrosine kinase with transmembrane and extracellular domains, showing high similarity to LTK.
It is crucial for the development and function of specific neurons in the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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