Thermo Fisher Scientific CORD2 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human, mouse, and rat CORD2 (CRX). Suitable for WB and IHC applications. Lyophilized form, reconstitute in sterile water. Store at 4°C short term or -20°C long term. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous (PubMed) | - | View 2 publications |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 250–300 of human CORD2 conjugated to an immunogenic carrier protein. Target family: CRX (UniProt ID: O43186-1). |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: CORD2.
Target Information
The cone-rod homeobox-containing gene (CRX) encodes a transcription factor that regulates the expression of multiple photoreceptor genes in the developing retina, including opsin and rhodopsin. CRX binds to the OTX motif (TAATCC/A) upstream of photoreceptor genes and is also expressed in pinealocytes, suggesting a role in circadian regulation via melatonin synthesis genes.
Mutations in CRX are associated with cone-rod dystrophy-2 (CORD2), Leber congenital amaurosis (LCA), and retinitis pigmentosa (RP). These mutations affect transcriptional domains, leading to visual disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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