Thermo Fisher Scientific Clusterin alpha Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: Clusterin alpha chain.

Target Information

Isoform 1 of Clusterin prevents stress-induced aggregation of blood plasma proteins. It inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA, and aggregation-prone LYZ variants (in vitro).
Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones such as HSPA8/HSC70.
Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation.
Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote ubiquitination and proteasomal degradation of target proteins.
Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity.
Nuclear isoforms promote apoptosis, while mitochondrial isoforms suppress BAX-dependent release of cytochrome c and inhibit apoptosis.
Plays a role in the regulation of cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: OSC00284W-100UL_Clusterin_Alpha_P10909-1_Rabbit.svg, OSC00284W-100UL_Clusterin_Alpha_P10909-1_Rabbit_PDP.jpeg)