Thermo Fisher Scientific Clusterin alpha Polyclonal Antibody
인간 Clusterin alpha 단백질을 인식하는 Rabbit Polyclonal Antibody. WB 및 IHC에 사용 가능하며, 1:200~1:2,000 희석 범위. 동결건조 형태로 제공되며, 장기 보관 시 -20°C 권장. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200–1:2,000 | View publications |
| Immunohistochemistry (IHC) | 1:200–1:2,000 | View publications |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 300–350 of human Clusterin conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: Clusterin alpha chain.
Target Information
Isoform 1 of Clusterin prevents stress-induced aggregation of blood plasma proteins. It inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA, and aggregation-prone LYZ variants (in vitro).
Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones such as HSPA8/HSC70.
Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation.
Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote ubiquitination and proteasomal degradation of target proteins.
Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity.
Nuclear isoforms promote apoptosis, while mitochondrial isoforms suppress BAX-dependent release of cytochrome c and inhibit apoptosis.
Plays a role in the regulation of cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: OSC00284W-100UL_Clusterin_Alpha_P10909-1_Rabbit.svg, OSC00284W-100UL_Clusterin_Alpha_P10909-1_Rabbit_PDP.jpeg)
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