Thermo Fisher Scientific Phospho-PKC beta-1 (Thr642, Thr644) Polyclonal Antibody
PKC beta-1 단백질의 Thr642 및 Thr644 인산화 상태를 특이적으로 검출하는 rabbit polyclonal antibody. Western blot 및 IHC(Paraffin)에서 검증됨. Human, Mouse, Rat에 반응하며, 1 mg/mL 농도의 액상 형태로 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | — |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PRKCB (Accession P05771), corresponding to amino acid residues around phosphorylated Thr642. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816891 |
Product Specific Information
Phospho-PKC beta 1 (Thr642+Thr644) Antibody detects endogenous levels of PKC beta 1 only when phosphorylated at Thr642 and Thr644.
Target Information
The PKC family of serine/threonine kinases, including PRKCB1 (PKC beta I), is activated intracellularly by signal transduction pathways.
In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in structure, tissue distribution, localization, and function.
PKC alpha, beta I, beta II, and gamma form the conventional PKC family, which are Ca²⁺- and phospholipid-dependent. PKC can be activated by calcium and diacylglycerol and phosphorylates various protein targets, participating in diverse signaling pathways.
PKC family members also serve as major receptors for phorbol esters, known tumor promoters. Each member has distinct expression profiles and roles in cells.
The PKC beta-1 protein is involved in multiple cellular functions such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption.
Mouse studies suggest additional roles in neuronal function and stress-related behavior. Alternative splicing results in distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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