Thermo Fisher Scientific Phospho-Cytokeratin 18 (Tyr36) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of Cytokeratin 18 only when phosphorylated at Tyr36.

Target Information

Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) is a type A (acidic) low molecular weight keratin that pairs with cytokeratin 8. It is expressed in tissues of the gastrointestinal, respiratory, and urogenital tracts, as well as in endocrine, exocrine, and mesothelial cells. Cytokeratin 18 is primarily found in non-squamous epithelia and is present in most adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas. Hepatocellular carcinomas express only cytokeratins 8 and 18. Mutations in the cytokeratin 18 gene are associated with cryptogenic cirrhosis. Two transcript variants encoding the same protein have been identified. Cytokeratin subtype expression is increasingly used to distinguish different epithelial malignancies. Cytokeratin antibodies are valuable in tumor differential diagnosis via immunohistochemistry, cytopathology, and flow cytometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.