Thermo Fisher Scientific PDI Recombinant Rabbit Monoclonal Antibody (JF97-08)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning antibody DNA sequences from immunoreactive rabbits. Selected clones are screened for optimal performance.
Key advantages include:

• Enhanced specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to the rabbit immune repertoire

Target Information

Protein disulfide isomerase (PDI) is a multifunctional enzyme that catalyzes the formation, breakage, and rearrangement of disulfide bonds.

• At the cell surface, PDI acts as a reductase, modifying exofacial proteins.
• Inside the cell, it assists in disulfide bond formation and rearrangement in nascent proteins.
• At high concentrations, it functions as a chaperone preventing aggregation of misfolded proteins, while at low concentrations it may promote aggregation.
• PDI also participates in hormone biogenesis and serves as a structural subunit in enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein (MTTP).
• It interacts with LGALS9, retaining P4HB at the cell surface of Th2 T helper cells, enhancing disulfide reductase activity and cell migration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.