Thermo Fisher Scientific Phospho-TSC2 (Tyr1571) Polyclonal Antibody

Applications and Tested Dilution

Species Reactivity

Human, Mouse, Rat

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TSC2 (Accession P49815), corresponding to amino acid residues around phosphorylated Tyr1571.

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Sequential chromatography

Storage Buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage Conditions

-20°C

Shipping Conditions

Wet ice

RRID

AB_2816652

Product Specific Information

This antibody detects endogenous levels of Tuberin/TSC2 only when phosphorylated at Tyr1571.

Target Information

TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2) is implicated as a tumor suppressor and may function in vesicular transport, regulation of cell growth arrest, and transcription mediated by steroid receptors.
TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Phosphorylation of tuberin on Ser939 and Thr1462 regulates its interaction with hamartin and is stimulated by growth factors through the PI3K/Akt pathway.
Mutations in TSC2 lead to constitutive activation of RAP1A in tumors and are involved in diseases such as lymphangioleiomyomatosis and TSC2 angiomyolipoma. Alternative splicing results in transcript variants of three different isoforms of TSC2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.