Thermo Fisher Scientific Lymphocyte Activation Gene 3 (LAG3) Monoclonal Antibody (OTI3C6)

Thermo Fisher Scientific Lymphocyte Activation Gene 3 (LAG3) Monoclonal Antibody (OTI3C6)

Applications and Tested Dilution

• Western Blot (WB): 1:150–1:500
• Flow Cytometry (Flow): 1:100

Product Specifications

Product Specific Information

• Reconstitute with 100 µL distilled water to achieve ~1 mg/mL final concentration.
• For conjugation experiments, perform additional desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
• Carrier-free format suitable for labeling or conjugation studies.

Target Information

LAG-3 (CD223) is a 70-kDa surface glycoprotein of the Ig superfamily with structural homology to CD4. It binds to MHC class II with higher affinity than CD4 and plays a role in negative regulation of T cell activation and homeostatic proliferation.
LAG-3 is expressed on activated T cells (including regulatory T cells) and NK cells. CD8+ T cells typically show higher LAG-3 expression than CD4+ T cells. Coexpression of LAG-3 and CD49b is used to identify Type 1 regulatory T cells (Tr1 cells) in human and mouse.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.

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