Thermo Fisher Scientific LAG3 Monoclonal Antibody (OTI5C3), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

LAG-3 (Lymphocyte Activation Gene 3) is a 70-kDa surface glycoprotein belonging to the Ig superfamily and shares structural homology with CD4.
It binds MHC class II molecules with higher affinity than CD4 and is involved in the negative regulation of T cell activation and homeostatic proliferation.
LAG-3 is expressed on activated T cells (including regulatory T cells) and NK cells, with CD8+ T cells typically showing higher expression than CD4+ T cells.
Coexpression of LAG-3 and CD49b has been proposed as a marker for Type 1 regulatory T cells (Tr1 cells) in humans and mice.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.