Thermo Fisher Scientific LAG3 Monoclonal Antibody (OTI5C3), TrueMAB
LAG3 단백질을 인식하는 Mouse IgG2b 단일클론 항체로, Western Blot 및 유세포분석에 사용 가능. 재조합 인간 LAG3(aa 66-332)을 면역원으로 제작. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:2,000 | |
| Flow Cytometry (Flow) | Assay-Dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5C3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 66–332 of human LAG3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
LAG-3 (Lymphocyte Activation Gene 3) is a 70-kDa surface glycoprotein belonging to the Ig superfamily and shares structural homology with CD4.
It binds MHC class II molecules with higher affinity than CD4 and is involved in the negative regulation of T cell activation and homeostatic proliferation.
LAG-3 is expressed on activated T cells (including regulatory T cells) and NK cells, with CD8+ T cells typically showing higher expression than CD4+ T cells.
Coexpression of LAG-3 and CD49b has been proposed as a marker for Type 1 regulatory T cells (Tr1 cells) in humans and mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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