Thermo Fisher Scientific HCN1 Monoclonal Antibody (S70), APC
HCN1 단백질을 검출하기 위한 APC 결합 단클론 항체로, 인간·마우스·랫트에 반응합니다. Western blot, IHC, ICC 등 다양한 응용에 적합하며, 단백질 G로 정제된 액상 형태입니다. 4°C 보관, 방부제 무첨가.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | Assay-dependent |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S70 |
| Immunogen | Fusion protein amino acids 778–910 (C-terminus) of rat HCN1 |
| Conjugate | APC (Allophycocyanin) |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 2 mM EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931853 |
Available Formats
- Unconjugated (Cat. MA5-27589)
- FITC (Cat. MA5-45400)
- PE (Cat. MA5-45402)
- PerCP (Cat. MA5-45401)
- Custom conjugation available upon request
Product Specific Information
- 1 µg/mL of MA5-45399 detects HCN1 in 10 µg of rat brain lysate by colorimetric immunoblot using Goat anti-mouse IgG:HRP as secondary antibody.
- Detects approximately 100 kDa.
- No cross-reactivity against HCN2.
Target Information
HCN1 (Hyperpolarization-activated cation channel 1) belongs to the HCN gene family, contributing to spontaneous rhythmic activity in heart and brain.
HCN1 channels are activated by hyperpolarization and regulated by cyclic nucleotides, playing key roles in motor learning, neuronal integration, and rhythmic neuronal activity.
Expression is enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus.
HCN2, in contrast, is abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body.
These regional variations contribute to differences in neuronal pacemaker activity across brain systems.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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