Thermo Fisher Scientific ESRRA Recombinant Rabbit Monoclonal Antibody (SC57-07)
Recombinant rabbit monoclonal antibody targeting ESRRA (Estrogen Related Receptor Alpha). Validated for WB, IHC(P), and Flow Cytometry. High specificity and lot-to-lot consistency with HEK293 expression system. Suitable for human, mouse, and rat samples.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SC57-07 |
| Immunogen | Synthetic peptide within Human Estrogen Related Receptor alpha (aa 1–49) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809481 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the large rabbit immune repertoire
Target Information
Estrogen-related receptor alpha 1 (ERRα, ERR1) is an orphan nuclear hormone receptor. ERR family members share an almost identical DNA-binding domain with 68% amino acid identity to the estrogen receptor. ERRα binds to the ERRα response element (ERRE) containing a single consensus half-site (5'-tnaaggtca-3') and can interact with the MCAD response element (NRRE-1), acting as a regulator of the MCAD promoter. ERR1 functions as a metabolic regulator and is expressed in tissues that preferentially metabolize fatty acids. The corresponding gene is NR3B1.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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