Thermo Fisher Scientific p16INK4a Recombinant Rabbit Monoclonal Antibody (RM267)
Thermo Fisher Scientific의 p16INK4a Recombinant Rabbit Monoclonal Antibody (RM267)은 인간 p16INK4a 단백질을 인식하는 고특이 항체로, WB, IHC, ICC/IF에 적합합니다. 재조합 기술로 생산되어 로트 간 일관성, 높은 민감도 및 특이성을 제공합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific p16INK4a Recombinant Rabbit Monoclonal Antibody (RM267)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RM267 |
| Immunogen | A peptide corresponding to the C-terminus of human p16INK4a (Cyclin-dependent kinase inhibitor 2A) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2744959 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
Target Information
This gene generates several transcript variants differing in their first exons. At least three alternatively spliced variants encode distinct proteins, two of which act as CDK4 kinase inhibitors.
Another transcript includes an alternate first exon located 20 Kb upstream, encoding an ARF protein that stabilizes p53 by interacting with and sequestering MDM2, preventing p53 degradation.
Despite structural and functional differences, all isoforms contribute to cell cycle G1 control through CDK4 and p53 regulation.
This gene is frequently mutated or deleted in various tumors and functions as an important tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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