Thermo Fisher Scientific Lactotransferrin/Lactoferrin/LTF Monoclonal Antibody (LTF/4072)
인간 Lactotransferrin(Lactoferrin, LTF)을 인식하는 Mouse monoclonal 항체로, IHC(P), Flow Cytometry, Peptide Array에 사용 가능. 단백질 A/G 정제, 200 µg/mL 농도, PBS + 0.05% BSA buffer. 인간 유즙선 및 전립선 조직에서 양성 대조로 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LTF/4072 |
| Immunogen | Recombinant fragment (around aa 614–645) of human Lactotransferrin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human lactating breast or prostate tissue
- Cellular Location: Cytoplasm, Secreted
Target Information
Lactoferrin (LF) is an iron-binding glycoprotein composed of a single polypeptide chain (~80 kDa) folded into two homologous lobes, each capable of reversibly binding one ferric ion (Fe³⁺). It is present in external fluids such as milk and mucosal secretions and is abundant in secondary granules of neutrophils.
Lactoferrin plays key roles in:
- Regulation of iron homeostasis
- Host defense against microbial infections
- Anti-inflammatory activity
- Regulation of cellular growth and differentiation
- Protection against cancer development and metastasis
LTF acts as a first-line defense by binding and removing Fe³⁺ from the environment and exhibits bactericidal and proteolytic activities. Three isoforms (LTF-α, LTF-β, LTF-γ) have been identified, and receptors are expressed in gastrointestinal tract cells, macrophages, lymphocytes, neutrophils, platelets, and certain bacteria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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