Thermo Fisher Scientific Lactotransferrin/Lactoferrin/LTF Monoclonal Antibody (LTF/4075)

Applications and Tested Dilution

Immunohistochemistry (Paraffin) (IHC (P))

• Assay-dependent

Immunohistochemistry (PFA fixed) (IHC (PFA))

• 1–2 µg/mL

Peptide Array (Array)

• Assay-dependent

Product Specifications

Target Information

Lactoferrin (LF) is an iron-binding glycoprotein composed of a single polypeptide chain (~80 kDa) folded into two homologous lobes, each capable of reversibly binding one ferric ion (Fe³⁺). It is found in external fluids such as milk and mucosal secretions and is a major component of neutrophil secondary granules.
LF plays multiple biological roles including:

• Regulation of iron homeostasis
• Host defense against microbial infections
• Anti-inflammatory activity
• Regulation of cellular growth and differentiation
• Protection against cancer development and metastasis

LTF serves as a first-line defense against microbial infections by binding and removing Fe³⁺, and also exhibits bactericidal and proteolytic activity. Three isoforms (LTF-α, LTF-β, LTF-γ) have been identified, and LTF receptors are expressed in the gastrointestinal tract, macrophages, lymphocytes, neutrophils, platelets, and certain bacteria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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