Thermo Fisher Scientific Spectrin beta III (SPTBN2) Recombinant Rabbit Monoclonal Antibody (SPTBN2/2887R)
Spectrin beta III(SPTBN2)에 특이적인 재조합 토끼 단일클론 항체로, WB, IHC, ICC/IF, Flow Cytometry에 사용 가능. HEK293 발현 시스템 기반, Protein A/G 정제, 200 µg/mL 농도. 인간 시료 반응성, 연구용 전용.
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카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Spectrin beta III (SPTBN2) Recombinant Rabbit Monoclonal Antibody (SPTBN2/2887R)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SPTBN2/2887R |
| Immunogen | Recombinant human SPTBN2 fragment (aa356–475) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Spectrins are principal components of the cell membrane-cytoskeleton and consist of two alpha and two beta spectrin subunits. The protein encoded by the SPTBN2 gene, also known as spectrin beta non-erythrocytic 2 or beta-III spectrin, is related to but distinct from beta-II spectrin (SPTBN1).
SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the plasma membrane surface.
Mutations in this gene are associated with spinocerebellar ataxia type 5 (SCA5), characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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