Thermo Fisher Scientific Spectrin beta III (SPTBN2) Monoclonal Antibody (SPTBN2/1778)
인간 SPTBN2 단백질을 인식하는 mouse monoclonal 항체로, WB, IHC, ICC 등 다양한 응용에 사용 가능. Protein A/G 정제, 200 µg/mL 농도의 액상 형태. 세포막-세포골격 관련 연구 및 신경퇴행 질환 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL | |
| Immunocytochemistry (ICC/IF) | 2–4 µg/mL | |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPTBN2/1778 |
| Immunogen | Recombinant fragment (around aa356–475) of human SPTBN2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Spectrins are principal components of the cell membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits.
The protein encoded by the SPTBN2 gene, known as spectrin beta non-erythrocytic 2 or beta-III spectrin, is related to but distinct from beta-II spectrin (SPTBN1).
SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the plasma membrane surface.
Mutations in this gene cause spinocerebellar ataxia type 5 (SCA5), characterized by neurodegeneration, locomotor incoordination, dysarthria, and uncoordinated eye movements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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